4-Aco DMT | 4-Acetoxy DMT (O-Acetylpsilocin Fumerate)

(16 customer reviews)


4-AcO-DMT-also known as O-acetylpsilocin, 4-acetoxy-DMT, psilacetin, or “synthetic mushrooms”—is a semi-synthetic research chemical in the tryptamine family, which also includes the classic psychedelics like DMT and psilocybin

4-AcO DMT Dose Ranges for Oral Ingestion

  • Microdose: 2.5 – 5 mg
  • Low Dose: 5 – 10 mg
  • Moderate Dose: 10 – 20 mg
  • High Dose: 20 – 40 mg
  • Heroic Dose: 40 mg +


SKU: N/A Category:


4-Acetoxy DMT (4-Aco DMT) Analytical Reference Standard, 250mg

4-acetoxy DMT also known as 4-Aco DMT is an O-acetylated psilocin that is believed to be a synthetic prodrug of psilocin, the psychedelic hallucinogen derived from various mushrooms. Although its pharmacological and toxicological properties are not well known, its activity has been proposed to be somewhat similar to that of psilocybin and psilocin. This product is intended for forensic and research applications.


  • Acetylpsilocin
  • 4-acetoxy-N,N-Dimethyltryptamine
  • O-Acetylpsilocin
  • Psilacetin


Formal Name
3-[2-(dimethylamino)ethyl]-1H-indol-4-ol-4-acetate, monohydrochloride
Molecular Formula
C14H18N2O2 • HCl
Formula Weight
A solution in acetonitrile
  • DMF: 30 mg/ml
  • DMSO: 10 mg/ml
  • Ethanol: 20 mg/ml
  • PBS (pH 7.2): 10 mg/ml
219, 277 nm
InChi Code
InChi Key


Wet ice in continental US; may vary elsewhere
≥ 2 years

What is 4-AcO-DMT?

4-AcO-DMT-also known as O-acetylpsilocin, 4-acetoxy-DMT, psilacetin, or “synthetic mushrooms”—is a semi-synthetic research chemical in the tryptamine family, which also includes the classic psychedelics like DMT and psilocybin. 4-AcO seems to be very closely related to the magic mushroom compounds psilocybin and psilocin, and like psilocybin, is speculated to break down into psilocin in the body during first pass metabolism.

In fact, 4-AcO-DMT was first synthesized in the early 1960s by Albert Hofmann, the same chemist who discovered LSD and first synthesized psilocybin. As an employee for the pharmaceutical company Sandoz, Hofmann and his colleague, Franz Troxler, were playing around with molecules similar to psilocin, and patented psilacetin along with four other esters (organic compounds that react to water by producing alcohol) of psilocin in 1963.

But 4-AcO was patented and then largely forgotten, until it reappeared in the 1990s rave scene as a new designer drug. Then in 1999, professor and psychedelic scientist David E. Nichols tried to put it on the map as a safe and cost-effective alternative to psilocybin, because it’s much easier (and cheaper) to synthesize but more than 20 years later, there still haven’t been any clinical studies on the safety, toxicity, or potential efficacy of O-acetylpsilocin, despite its rising popularity among psychonauts.

Today, psilacetin is comes in the form of a brown or off-white powder (technically a fumarate salt) that can be taken orally or intranasally in micro-doses or more, depending how hard you want to trip—which, depending on how many milligrams one takes, can resemble the effects of mushrooms or DMT, causing many to speculate that 4-AcO has psychedelic properties of its own.

4-AcO-DMT Dosage

Before I start to explain what the 4-AcO trip is like, it’s important to emphasize just how dose-dependent the research chemical is. The general consensus among users on message boards and the nine people who filled out a survey I created on 4-AcO, is that lower doses feel like a psilocybin experience, while higher doses start to more so resemble a DMT experience. Or as Sarah*, one of my survey participants, put it, “It was like mushrooms, DMT, and acid in one… like a long DMT trip with the warm and loving feeling of mushrooms, and the mind-blowing experience of acid.”

4-AcO Dose Ranges for Oral Ingestion

  • Microdose: 2.5 – 5 mg
  • Low Dose: 5 – 10 mg
  • Moderate Dose: 10 – 20 mg
  • High Dose: 20 – 40 mg
  • Heroic Dose: 40 mg +

A general reference point indicates that many individuals consider oral doses in the 15 to 20 mg range to closely resemble a 3.5-gram magic mushroom experience. Like all new psychedelics, it’s advisable to commence with a low to moderate dose or even microdose for your initial trip. This approach allows you to familiarize yourself with the terrain before delving into more intense experiences.

For nasal ingestion, doses will differ slightly, as many individuals claim that snorting the powder leads to a stronger but potentially shorter-acting experience. Additionally, a survey participant highlighted the possibility of the powder turning blue in your nostrils. If this occurs, there’s no need for alarm, as it seems to be a common phenomenon.

4-AcO Dose Ranges for Intranasal Ingestion:

  • Microdose: less than 5 mg
  • Low Dose: 5 – 10 mg
  • Moderate Dose: 10 – 20 mg
  • High Dose: 20 – 30 mg
  • Heroic Dose: 30 mg +

For safe dosing, be sure to weigh out your dose on a scale that can read milligrams and if you don’t own one, you should consider investing. They don’t cost more than about $20 and are an easy way to practice harm reduction. Especially with research chemicals that come as powders, a small amount can have a big impact on the strength of the experience.

O-acetylpsilocin Duration

Most folks report an O-acetylpsilocin trip to last more or less the same amount of time as mushrooms but from four to eight hours with an afterglow lasting up to 48 hours after the experience has ended.

Psychonaut Wiki has mapped out the duration as such:

  • Total: 4 – 7 hours
  • Onset: 15 – 40 minutes
  • Come Up: 30 – 75 minutes
  • Peak: 2 to 3.5 hours
  • Offset: 1 – 2 hours
  • After effects: 4 – 48 hours

4-AcO DMT Trip 

The 4-AcO trip is very dose-dependent. The most common way people describe it is the trip being like a crisp, lucid, and warm mushroom experience on low and moderate doses of about 15 to 30 mg. “4-AcO has a very light and joyous character, almost childlike. Like mushrooms but crisper and clearer,” wrote Steven*, one of my survey respondents, who’s tried 4-AcO at doses ranging from 10 to 50 mg several hundred times. “It’s slightly gentler and more simplified of a trip than mushrooms, but almost the same feeling.”

Buy 4-AcO-DMT Deadhead Chemist Microdose | Microdosing Deadhead Chemist 4-AcO-DMT

DMT is illegal in most parts of the world and we do not promote the use of this substance in such areas. For users that decide to use this substance, we provide a complete guide about the substance to ensure that all its users are kept safe.

So What Exactly Is Buy 4-AcO-DMT Deadhead Chemist?

N,N-Dimethyltryptamine (DMT) is a psychoactive chemical substance found naturally in some plants, animals, and even the human brain, exposing us to this substance. Some cultures utilize DMT for ritual purposes, aiming to alter their consciousness and mood.

The Amazonians, for instance, utilize DMT found in ayahuasca for their psychedelic experiences. Discovered by Albert Hofmann and Franz Troxler, the same individuals who found LSD, DMT was patented by Sandoz Limited in 1963.

Various methods exist for ingesting DMT, with many opting for its crystal form. Smoking it through a pipe or bong, or injecting it, result in powerful yet short trips, believed to be among the most potent hallucinogenic experiences.

Among the numerous “grey market” research chemicals, Buy 4-AcO-DMT Deadhead Chemist stands out as one of the safest. This synthetic psychedelic tryptamine shares structural similarities with the molecules found in “magic mushrooms,” namely psilocybin and psilocin.

Many Benefits Come With The Consumption Of The DMT Microdose 4-ACO-Microdosing/4-Acetoxy-N,N-Dimethyltryptamine (Psilacetin Or 4-AcO-DMT)

It creates a feeling of peace and relaxation in the mind and body.
4-Aco enhances the sense of positivity in our mood.
This gives us a stronger feeling of empathy and community.
It gives us the strength to focus and also ensures the mind is free of all negativities.
4 Aco DMT enhances colours and intensifies one’s physical perception.
It energizes and drives us on.
With microdose of DMT users will find an increase in focus, decrease in anxiety, or easier access to flow states

How To Microdose With Buy 4-AcO-DMT Deadhead Chemist?

Deadhead Chemist typically sells 4-AcO-DMT in a crystallized or powdered form, facilitating various ingestion methods, including oral consumption. However, the preferred and simplest approach is oral intake, despite the substance’s unfavorable taste.

When determining your desired dose, it is crucial to note that altering a few milligrams can significantly impact your experience. According to scientific analysis and reports, the optimal microdose volume falls between 0.5mg and 5mg. If you’re a novice DMT user, it’s advisable to stick to lower volumes, as doses as high as 5mg can be challenging for some individuals.

For beginners, commencing with 1mg allows you to assess your experience for subsequent measurements. Nevertheless, since most scales are not perfectly accurate with such minute amounts, employing the volumetric microdosing method ensures precise dosage confirmation.

Additional information


2 grams, 5 grams, 10 grams, 1/2 ounce, 1 ounce

16 reviews for 4-Aco DMT | 4-Acetoxy DMT (O-Acetylpsilocin Fumerate)

  1. Nathaniel (verified owner)

    Good service.

  2. Finley

    My girlfriend and I had to time of our lives with this product

  3. Sunny

    4-Ac0-DMT is definitely scary but can make the journey more friendly

  4. Cassian

    Great experience tripping with 4-Ac0-DMT

  5. Laurie

    First time tripping with 4-Ac0 and I’m glad I ordered from you guys because then I’m sure of the quality

  6. Adonis

    My wife and I had been looking for a reliable source of 4-AcO and we only got scammed till I recently when we gave darknet pharmaceutical a try and today we received our package. Cheers!!

  7. Rocky

    I didn’t make a mistake ordering from darknet pharmaceutical. You rock!!

  8. Eden

    4-AcO ever. Order from darknet pharmaceutical

  9. Greck

    7 days and it made it all the way to Australia without any problems. This team deserves an award for the good job you do.

  10. Kylo

    Best begining of the year ever thank darknet pharmaceutical. Received package on time and product was of good quality

  11. Anakin

    Wow! Best price I have ever received. With amazing discount.

  12. Jodan

    I love the customer service and delivery team.

  13. Gralion

    Fascinating product you got here! The purity of your DMT is extraordinary, I’m satisfied with my order. Kudos!!

  14. Eveline

    Super excellent products and services team

  15. Sylvia

    Always grateful for darknet for been there for the less privilege

  16. Comfort

    More likeable for 4-ACO to take over the leading products because it’s the best out of the best

Add a review

Your email address will not be published. Required fields are marked *

You cannot copy content of this page